Sinopsis
Peter Parker decide irse junto a Michelle Jones, Ned y el resto de sus amigos a pasar unas vacaciones a Europa después de los eventos ocurridos en Vengadores: EndGame. Sin embargo, el plan de Parker por dejar de lado sus superpoderes durante unas semanas se ven truncados cuándo es reclutado por Nick Fury para unirse a Mysterio (un humano que proviene de la Tierra 833, una dimensión del multiverso, que tuvo su primera aparición en Doctor Strange) para luchar contra los elementales (cuatro entes inmortales que vienen de la misma dimensión y que dominan los cuatro elementos de la naturaleza, el fuego, el agua, el aire y la tierra) . En ese momento, Parker vuelve a ponerse el traje de Spider-Man para cumplir con su labor.
Reparto
Tom Holland — Peter Parker / Spider-ManJake Gyllenhaal — Quentin Beck / MysterioSamuel L. Jackson — Nick FuryMarisa Tomei — May ParkerJon Favreau — Happy HoganZendaya — MJJacob Batalon — Ned LeedsTony Revolori — Flash ThompsonAngourie Rice — Betty BrantRemy Hii — Brad DavisMartin Starr — Mr. HarringtonJB Smoove — Mr. DellJorge Lendeborg Jr. — Jason IonelloCobie Smulders — Maria HillNuman Acar — DimitriZach Barack — ZachZoha Rahman — ZohaYasmin Mwanza — YasminJoshua Sinclair-Evans — JoshTyler Luke Cunningham — TylerSebastián Viveros — SebastianToni Garrn — The SeamstressPeter Billingsley — William Ginter RivaClare Dunne — VictoriaNicholas Gleaves — GutermanClaire Rushbrook — JaniceJ.K. Simmons — J. Jonah JamesonDawn Michelle King — E.D.I.T.H. (voice)Jeroen van Koningsbrugge — Dutch Soccer HooliganMichael de Roos — Dutch Soccer HooliganJan-Paul Buijs — Dutch Soccer HooliganSergio Pierattini — Venetian GlassblowerAnjana Vasan — Queens ReporterBrian Law — Queens ReporterEvelyn Mok — Queens ReporterTatiana Lunardon — Italian TV NewsreaderGiada Benedetti — Italian Customs OfficeLukáš Bech — Helpful Dutch ManAlessandro Giuggioli — Italian Street VendorPetr Opava — Opera SingerGiuseppe Andriolo — CaricaturistPat Kiernan — Pat KiernanShari Abdul — High School Reporter (uncredited)Mari Alexandrova — Tourist in Venice (uncredited)Kristen Alminta — Police Officer (uncredited)Vincent Angel — Midtown High Student (uncredited)Peter Arpesella — Airplane Pilot (uncredited)Lasco Atkins — Salvation Army guest (uncredited)Sitara Attaie — Dutch Lady (uncredited)Peter Bankolé — Mob Boss (uncredited)Blair Barnette — Queens Reporter (uncredited)Tuwaine Barrett — Officer Bristow (extended cut)Anna Benamati — Shop Owner in Venice (uncredited)Bruno Bilotta — Mob Boss (uncredited)Sharon Blynn — Soren (uncredited)Luigi Boccanfuso — Italian Builder in Venice (uncredited)Paolo Braghetto — Poliziotto (uncredited)Dante Brattelli — High School Student (uncredited)Graham Burton — London Passerby (uncredited)Ken Byrd — Post Office Customer (uncredited)Sokol Cahani — Mob Boss (uncredited)Darren Lee Campbell — Victoria's Crew (uncredited)Hélène Cardona — Austrian Backpacker (uncredited)Dian Cathal — American Reporter (uncredited)Jake Cerny — Airport Traveler (uncredited)Daphne Cheung — Passport Clerk (uncredited)Sam Chuck — High School Student (uncredited)Victoria Coburn — Passerby (uncredited)Kimberly Collison — Charity Event Mom (uncredited)Tiziana Coste — Local Venetian (uncredited)Jaylen Davis — Tourist (uncredited)Kristianne-Kaith Domingo — Passerby (uncredited)Andrew Dunkelberger — Courier (uncredited)Charlie Esquér — Mexican Survivor (uncredited)Ria Fend — Tourist in Venice (uncredited)Ferroz Fernandez — Tourist in Venice (uncredited)Vincent Frattini — Venice Local (uncredited)Massi Furlan — Flight Attendant (uncredited)Cynthia Garbutt — Charity Dinner Guest (uncredited)Thomas Goodridge — Tourist in Venice (uncredited)Sonia Goswami — Tourist (uncredited)Nicholle Hembra — Saved Londoner (uncredited)Michael Hennessy — Hotel Guest (uncredited)Meagan Holder — Pretty Tourist (uncredited)Patrick Doran — Partygoer (uncredited)Ruth Clarson — Tourist (uncredited)Chris Hyacinthe — Sneezy Tour Guide (uncredited)Michael Iacono — Airport Kid Traveler (uncredited)Roman Ibragimov — Bar Customer (uncredited)Theo Ip — Tourist (uncredited)Timothy Christian Jansen — High School Student (uncredited)Keon Kendrick — Flight Attendant (uncredited)Camille Kinloch — Midtown High School Student (uncredited)Michal Kubal — Czech TV News Anchor (uncredited)Hannah Kurczeski — Student (uncredited)Géraldine Lamarre — Traffic Warden (uncredited)Jimena Larraguivel — Mexican Villager (uncredited)Rich Lawton — Journalist (uncredited)Kat Leroy — Czech Traditional Dancer (uncredited)Gavin Lee Lewis — Londoner (uncredited)Patrick Loh — Airport Passenger (uncredited)Joseph Long — Mob Boss (uncredited)Marian Lorencik — New Czech Reveler (uncredited)Ketan Majmudar — Berlin Commuter (uncredited)Tony Mardon — Londoner (uncredited)Antonín Mašek — Bellboy (uncredited)Ben Mendelsohn — Talos (uncredited)Bradley Wj Miller — Passerby (uncredited)Melissa Beth Miller — Tourist (uncredited)Anthony Molinari — Mob Guy (uncredited)Adrian Mozzi — Venice Local (uncredited)Brendan Murphy — Police Officer (uncredited)Amanda Musso — Carnival Hot Girl (uncredited)Emily Ng — Italian Tourist (uncredited)Daniel Olson — Czech Guy (uncredited)Hiten Patel — British Station Staff (uncredited)Luigi Petrazzuolo — Gondolier (uncredited)Aleksandrs Petukhovs — London Passerby (uncredited)Annie Pisapia — Traveler (uncredited)Jivan Xander Ramesh — Pedestrian (uncredited)Mike Ray — Passerby (uncredited)Sofia Renee — High School Student (uncredited)Cailan Robinson — Victoria's Crew (uncredited)Ray Rosario — TSA Agent (uncredited)Daniel Ryves — Dad Collecting Kids (uncredited)Maurice Sardison — Party Goer (uncredited)Karen-J Sear — American Tourist (uncredited)Ilya Tank Shilov — Venice Tourist (uncredited)Davina Sitaram — London Tourist (uncredited)Joakim Skarli — London Tourist (uncredited)Lucas Antoine Starrets — Tourist (uncredited)Faith Tarby — Perfumed Lady (uncredited)Emily Tebbutt — Venice Tourist (uncredited)Lesdy Vanessa — Tourist (uncredited)Jessica VanOss — Student (uncredited)Joe David Walters — Pawn Shop Owner (uncredited)Jo Wheatley — Armed Security Officer (uncredited)Rocco Wu — Peter's Art Classmate (uncredited)Samantha Mishinski — Student (uncredited)Aristou Meehan — Italian Boy (uncredited)Robert Downey Jr. — Tony Stark (Uncredited)Jeff Bridges — Obadiah Stane (Uncredited)